Table 2.
Univariate and multivariate analysis for factors effecting.
| Variable | Univariate HR (95%CI) | p-value | Multivariate HR (95%CI) | p-value |
|---|---|---|---|---|
| Age | ||||
| <65 | 1 (Ref) | 0.45 | ||
| ≥65 | 1.67 (0.44–6.31) | |||
| Gender | ||||
| Male | 1 (Ref) | 0.99 | ||
| Female | 1.00 (0.44–6.31) | |||
| Body mass index | ||||
| ≥20 | 1 (Ref) | 0.78 | ||
| <20 | 0.95 (0.68–3.21) | |||
| Socioeconomic status | ||||
| High income | 1 (Ref) | 0.18 | 1 (Ref) | 0.22 |
| Low to moderate income | 4.11 (0.53–31.74) | 3.73 (0.45–31.25) | ||
| Education | ||||
| High school/undergraduate | 1 (Ref) | 0.72 | ||
| Illiterate/primary school | 1.27 (0.35–4.68) | |||
| Smoking | ||||
| No | 1 (Ref) | 0.39 | ||
| Yes | 0.61 (0.20–1.88) | |||
| Alcohol | ||||
| No | 1 (Ref) | 0.50 | ||
| Yes | 1.51 (0.47–1.80) | |||
| Albumin | ||||
| ≥35 g/L | 1 (Ref) | 0.001 | 1 (Ref) | 0.055 |
| <35 g/L | 9.11 (2.42–34.33) | 4.161 (0.97–17.87) | ||
| Prealbumin | ||||
| ≥200 mg/L | 1 (Ref) | 0.001 | 1 (Ref) | 0.041 |
| <200 mg/L | 4.47 (1.81–11.07) | 2.89 (1.05–7.99) | ||
| Preoperative neutrophil count | ||||
| ≥2.0*109/L | 1 (Ref) | 0.004 | 1 (Ref) | 0.007 |
| <2.0*109/L | 4.48 (1.61–12.49) | 5.00 (1.54–16.25) | ||
| Preoperative lymphocyte | ||||
| ≥1.1*109/L | 1 (Ref) | 0.681 | ||
| <1.1*109/L | 0.77 (0.21–2.74) | |||
| Preoperative hemoglobin | ||||
| ≥110 g/L | 1 (Ref) | 0.334 | ||
| <110 g/L | 1.57 (0.63–12.49) | |||
| Serum CEA | ||||
| Normal | 1 (Ref) | 0.765 | ||
| Elevated | 1.15 (0.46–2.84) | |||
| Renal function | ||||
| Normal | 1 (Ref) | 0.367 | ||
| Dysfunction | 0.62 (0.22–1.75) | |||
| PNI | ||||
| ≥51.2 | 1 (Ref) | 0.005 | 1 (Ref) | 0.049 |
| <51.2 | 8.39 (1.91–36.75) | 4.76 (1.01–22.49) | ||
| Differentiation | ||||
| High/moderate | 1 (Ref) | 0.009 | 1 (Ref) | 0.230 |
| Poor | 3.98 (1.42–11.11) | 2.04 (0.64–6.50) | ||
| TNM stage | ||||
| II | 1 (Ref) | 0.473 | ||
| III | 1.40 (0.58–3.23) | |||
| Lymph node metastasis | ||||
| No | 1 (Ref) | 0.028 | 1 (Ref) | 0.228 |
| Yes | 3.48 (1.14–10.59) | 2.14 (0.62–7.42) | ||
| Complication | ||||
| No | 1 (Ref) | 0.614 | ||
| Yes | 1.348 (0.42–4.30) | |||
For p-value: Boldface type indicates significant difference.
HR, hazard ratio;SD, standard deviation; eGFR, estimated glomerular filtration rate; CEA, carcinoembryonic antigen; TNM, tumor-node-metastasis; AC, adjuvant chemotherapy; PNI, prognostic nutritional index.