TABLE 4.
Suggestive findings of the meta-analysis (p-value ≤ 3.02 × 10–4).
| rsID | Gene | Chr | Position* | REF/ALT | GVS function** | PolyPhen score** | PhastCons score** | CADD score** | β | SE | p-value | Direction† |
| 8:146017422 | RPL8 | 8 | 146017422 | G/A | Synonymous | Unknown | 0.999 | 15.11 | 1.93 | 0.40 | 1.48 × 10–6 | +++ |
| rs77919685 | LATS2 | 13 | 21563311 | G/A | Missense | 0.002 | 0 | 7.001 | 0.44 | 0.09 | 2.23 × 10–6 | +++ |
| rs56041036 | ZFPM1 | 16 | 88599023 | A/G | Synonymous-near-splice | Unknown | 0.998 | 10.77 | –0.20 | 0.04 | 7.44 × 10–6 | −−− |
| rs199779997 | MGA | 15 | 42058958 | A/C | Missense | 0.001 | 0.866 | 9.45 | 1.77 | 0.40 | 8.60 × 10–6 | +++ |
| rs4895944 | VNN2 | 6 | 133070995 | G/T | Missense, non-coding-exon | 0.038 | 0.003 | 16.69 | –1.29 | 0.29 | 8.99 × 10–6 | −−? |
| rs7735563 | RAPGEF6 | 5 | 130764936 | T/C | Intron | Unknown | 1 | 19.08 | –0.77 | 0.18 | 1.53 × 10–5 | −−− |
| rs189691392 | SF3B5 | 6 | 144416667 | G/A | 5-prime-UTR | Unknown | 0 | 7.119 | –1.82 | 0.42 | 1.77 × 10–5 | -?- |
| rs138765444 | ZKSCAN4 | 6 | 28219377 | A/G | Synonymous, intron | Unknown | 0.036 | 9.324 | –1.27 | 0.30 | 2.59 × 10–5 | −−− |
| rs1783091 | none | 21 | 33964605 | T/C | Intergenic | Unknown | 0.004 | 0.154 | 0.22 | 0.05 | 2.67 × 10–5 | +?+ |
| rs2170177 | DOCK3 | 3 | 51349887 | C/A | Intron | Unknown | 0 | 0.044 | –0.36 | 0.09 | 5.06 × 10–5 | −−− |
| rs5930 | LDLR | 19 | 11224265 | A/G | Synonymous | Unknown | 0.001 | 0.579 | –0.10 | 0.03 | 5.73 × 10–5 | −−− |
| rs55648406 | TUB | 11 | 8060566 | G/A | Missense, intron | 0.086 | 1 | 15.76 | –0.62 | 0.16 | 5.85 × 10–5 | −−− |
| rs140456008 | SLC35G2 | 3 | 136574420 | A/G | Missense | 0.941 | 1 | 10.84 | 1.89 | 0.47 | 6.67 × 10–5 | ++? |
| rs139380413 | COL8A1 | 3 | 99513830 | G/A | Missense | 0.071 | 0.966 | 11.23 | –1.26 | 0.32 | 7.88 × 10–5 | −−− |
| rs11656725 | LRRC48 | 17 | 17900726 | C/T | Intron | Unknown | 0 | 0.471 | 0.38 | 0.10 | 8.25 × 10–5 | +?+ |
| rs7193541 | RFWD3 | 16 | 74664743 | T/C | Missense | 0.008 | 0.485 | 9.1 | –0.10 | 0.03 | 8.28 × 10–5 | −−− |
| rs17222435 | SLC28A1 | 15 | 85488335 | C/T | Intron | Unknown | 0 | 3.598 | 0.69 | 0.18 | 9.07 × 10–5 | +++ |
| rs117223521 | none | 8 | 38964715 | T/C | Upstream-gene | Unknown | 0 | 1.194 | –1.36 | 0.35 | 1.01 × 10–4 | -?- |
| rs11700220 | MTG2 | 20 | 60770931 | A/G | Missense | 1 | 1 | 21.6 | 0.47 | 0.12 | 1.03 × 10–4 | +++ |
| rs187466877 | GPN1 | 2 | 27862872 | A/G | Intron | Unknown | 0 | 1.47 | 0.85 | 0.22 | 1.05 × 10–4 | +?+ |
| rs56188826 | MARK1 | 1 | 220791870 | C/T | Synonymous | Unknown | 0.123 | 6.414 | 0.41 | 0.11 | 1.14 × 10–4 | +?+ |
| rs1872592 | PIF1 | 15 | 65113493 | G/A | Intron | Unknown | 0 | 0.005 | –0.10 | 0.02 | 1.15 × 10–4 | −−− |
| rs73056605 | CLEC4C | 12 | 7894056 | G/A | Missense | 0.037 | 0 | 0.005 | 0.11 | 0.03 | 1.18 × 10–4 | +++ |
| rs181080831 | RTEL1, RTEL1-TNFRSF6B | 20 | 62326874 | G/A | Intron, non-coding-exon, synonymous | Unknown | 0 | 4.04 | 0.74 | 0.19 | 1.18 × 10–4 | +++ |
| rs13014800 | CENPA | 2 | 27015118 | G/A | Intron | Unknown | 0.163 | 11.67 | –0.13 | 0.03 | 1.23 × 10–4 | -?- |
| rs143463783 | TRIM27 | 6 | 28889741 | G/A | Synonymous | Unknown | 1 | 9.216 | –1.22 | 0.32 | 1.24 × 10–4 | -?- |
| rs374215951 | PIEZO1 | 16 | 88788318 | G/A | Synonymous | Unknown | 0.21 | 0.893 | –2.57 | 0.67 | 1.31 × 10–4 | -?- |
| rs181215404 | EPPK1 | 8 | 144941659 | G/A | Synonymous | Unknown | 0.011 | 4.835 | 0.94 | 0.25 | 1.32 × 10–4 | +?+ |
| rs377359525 | FTCD | 21 | 47572869 | A/G | Missense | 1 | 1 | 16.44 | 1.68 | 0.44 | 1.33 × 10–4 | +++ |
| rs10936599 | MYNN | 3 | 169492101 | C/T | Synonymous, non-coding-exon, 5-prime-UTR | Unknown | 1 | 10.1 | –0.11 | 0.03 | 1.38 × 10–4 | −−− |
| rs74730846 | STXBP5L | 3 | 120924764 | C/T | Intron-near-splice | Unknown | 0.629 | 5.818 | –0.19 | 0.05 | 1.39 × 10–4 | -?- |
| rs137853096 | HSD17B4 | 5 | 118788316 | G/A | Missense, 5-prime-UTR | 1 | 1 | 24 | –0.73 | 0.19 | 1.67 × 10–4 | −−? |
| rs41284136 | IFIT3 | 10 | 91087805 | G/C | 5-prime-UTR | Unknown | 0 | 7.796 | 0.40 | 0.11 | 1.76 × 10–4 | +++ |
| rs58106741 | SLC4A1AP | 2 | 27886820 | G/T | Synonymous | Unknown | 0 | 5.939 | 0.70 | 0.19 | 1.80 × 10–4 | +?+ |
| rs58068845 | UTP6 | 17 | 30200363 | G/A | Intron | Unknown | 0 | 4.223 | 0.35 | 0.09 | 1.90 × 10–4 | +++ |
| rs200602887 | GREB1 | 2 | 11751072 | G/C | Synonymous | Unknown | 0.986 | 10.5 | –1.02 | 0.27 | 2.01 × 10–4 | −−− |
| rs141180155 | LRP2 | 2 | 170127559 | G/A | Synonymous, intron | Unknown | 0 | 13.06 | –0.36 | 0.10 | 2.08 × 10–4 | −−− |
| rs7837242 | LONRF1 | 8 | 12600622 | C/T | Intron | Unknown | 0.001 | 4.941 | –0.18 | 0.05 | 2.08 × 10–4 | -?- |
| rs115018606 | C2orf16 | 2 | 27799773 | A/C | Missense | 0.972 | 0.002 | 5.869 | 0.41 | 0.11 | 2.12 × 10–4 | +?+ |
| rs151309008 | REXO2 | 11 | 114310345 | C/T | Missense | 0.437 | 1 | 17.76 | –0.64 | 0.17 | 2.12 × 10–4 | −−− |
| rs143759519 | PYGL | 14 | 51382637 | G/A | Missense | 1 | 0.975 | 34 | 0.55 | 0.15 | 2.13 × 10–4 | +++ |
| rs10936600 | LRRC34 | 3 | 169514585 | A/T | Missense | 1 | 0.001 | 12.07 | –0.11 | 0.03 | 2.14 × 10–4 | −−− |
| rs117178504 | DYNC2H1 | 11 | 103153788 | C/A | Synonymous | Unknown | 0.996 | 8.615 | 0.38 | 0.10 | 2.18 × 10–4 | +++ |
| rs367644268 | COA5 | 2 | 99224742 | C/T | Intron | Unknown | 0.015 | 8.626 | –1.42 | 0.39 | 2.28 × 10–4 | −−? |
| rs146979490 | GPN1 | 2 | 27864089 | A/G | Intron | Unknown | 0.025 | 11.52 | 0.51 | 0.14 | 2.43 × 10–4 | +++ |
| rs146033252 | MTA3, OXER1 | 2 | 42991127 | G/A | Missense, intron | 0.084 | 0.023 | 8.404 | 0.71 | 0.19 | 2.48 × 10–4 | +++ |
| rs141280036 | PADI4 | 1 | 17634718 | A/G | Missense | 0.992 | 0.881 | 13.72 | 0.79 | 0.22 | 2.51 × 10–4 | +++ |
| rs79400176 | DZANK1 | 20 | 18414309 | C/T | Missense | 0.129 | 0.994 | 2.801 | –0.36 | 0.10 | 2.55 × 10–4 | −−− |
| rs116604207 | RBM5 | 3 | 50147061 | G/A | Synonymous, non-coding-exon | Unknown | 0.453 | 11.12 | 0.79 | 0.22 | 2.62 × 10–4 | +++ |
| rs41307740 | LBR | 1 | 225601614 | C/A | Intron | Unknown | 0.004 | 5.956 | –0.65 | 0.18 | 2.76 × 10–4 | -?- |
| rs369623673 | ELAC2 | 17 | 12899160 | C/T | Intron | Unknown | 0 | 6 | 0.93 | 0.26 | 2.77 × 10–4 | +?+ |
| rs9997727 | C4orf50 | 4 | 5969113 | G/A | Intron | Unknown | 0 | 0.613 | –0.10 | 0.03 | 2.85 × 10–4 | −−− |
| rs150538926 | PDZD2 | 5 | 32037369 | C/T | Synonymous | Unknown | 0 | 0.482 | 0.40 | 0.11 | 2.87 × 10–4 | +++ |
| rs55868421 | TRIM5 | 11 | 5688948 | A/G | Intron-near-splice, intron | Unknown | 0 | 5.512 | 0.44 | 0.12 | 2.94 × 10–4 | +++ |
| rs323895 | ACY1, ABHD14A- ACY1 | 3 | 52021316 | A/G | Intron | Unknown | 0 | 1.818 | –0.36 | 0.10 | 3.00 × 10–4 | −−− |
| rs7188880 | RFWD3 | 16 | 74664810 | A/T | Synonymous | Unknown | 1 | 10.78 | –0.09 | 0.02 | 3.01 × 10–4 | −−− |
Chr = Chromosome; REF = Reference allele; ALT = Alternative allele; CADD = Combined Annotation Dependent Depletion; β = effect of the minor allele; SE = Standard Error. *Position according to Hg19. **Seattleseq Annotation Database 138. †Order of cohorts in direction column: ERF, RS, BHF-FHS; Direction of effect represented by − (negative association) + (positive association) or ? (not available).