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. Author manuscript; available in PMC: 2020 May 7.
Published in final edited form as: Neurobiol Dis. 2020 Jan 13;137:104746. doi: 10.1016/j.nbd.2020.104746

Fig. 5.

Fig. 5.

Specific increase in the AMPA/NMDA ratio at Pf-MSN synapses in St-GluD1 KO. A. Viral vector injections in the Pf (top row) and resulting anterograde labeling of the thalamic projections in the dorsal striatum (bottom row) in WT and St-GluD1 KO mice. B. Light-evoked EPSCs (in the presence of picrotoxin (PCTX)), sensitive to CNQX and AP5, were recorded in striatal MSNs (** p < .01). C. No significant change in paired-pulse ratio across different inter-stimulus interval was observed between WT and KO animals [p > .876 for all intervals, Two-way ANOVA with Bonferroni’s post-hoc test (N = 7–10 from 3 to 4 animals per genotype)]. D. A significant increase in the AMPA/NMDA ratio was observed at Pf-MSN synapses in St-GluD1 KO [WT 0.35 ± 0.05 vs. St-GluD1 KO 0.98 ± 0.24, p = .033; Unpaired t-test (N = 8–10 from 3 to 4 animals per genotype)]. E. No change in the rectification of AMPA receptor responses in St-GluD1 KO; p > .999 for all voltages; Two-way ANOVA with Bonferroni’s post-hoc test (N = 6 from 3 animals per genotype). All data are presented as mean ± SEM.