Table 2.

Subgroup analysis for outcomes.

	Number of comparisons	Results	P value for overall effect	I2	P value for subgroup difference
Total effective rate		Risk ratio (95% CI)
All comparisons	10	1.26 (1.12, 1.41)	0.0001	77%
Course of treatment					0.98
1 month	5	1.27 (1.03, 1.56)	0.02	89%
2 months	4	1.26 (1.06, 1.50)	0.008	49%
3 months	1	1.24 (1.04, 1.47)	0.01	NA
Intervention of treatment group					0.63
Monotherapy	3	1.34 (1.02, 1.74)	0.03	66%
Combined	7	1.24 (1.07, 1.43)	0.003	82%
Tear Film Break Up Time		Mean difference (95% CI)
All comparisons	11	3.84 (2.91, 4.76)	<0.00001	65%
Course of treatment					0.0001
1 month	6	2.59 (2.09, 3.09)	<0.00001	39%
2 months	4	3.84 (2.91, 4.76)	<0.00001	65%
3 months	1	1.12 (0.26, 1.98)	0.01	NA
Intervention of treatment group					0.23
Monotherapy	3	3.49 (2.85, 4.13)	<0.00001	0%
Combined	8	2.81 (1.92, 3.71)	<0.00001	87%
Baseline value					0.98
High baseline	4	2.90 (2.09, 3.71)	<0.00001	32%
Low baseline	7	2.92 (1.92, 3.91)	<0.00001	89%
Schimer’s Test		Mean difference (95% CI)
All comparisons	9	2.94 (1.83, 4.04)	<0.00001	95%
Course of treatment					0.0002
1 month	4	1.76 (1.11, 2.41)	<0.00001	27%
2 months	4	4.28 (3.27, 5.29)	<0.00001	90%
3 months	1	2.81 (1.24, 3.12)	<0.00001	NA
Intervention of treatment group					<0.0001
Monotherapy	3	5.00 (4.73, 5.27)	<0.00001	0%
Combined	6	1.98 (1.55, 2.40)	<0.00001	9%
Baseline value					<0.00001
High baseline	3	5.07 (4.73, 5.27)	<0.00001	0%
Low baseline	6	1.97 (1.53, 2.42)	<0.00001	9%

NA, not appliable