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. Author manuscript; available in PMC: 2020 May 7.
Published in final edited form as: Exp Neurol. 2019 Feb 26;317:100–109. doi: 10.1016/j.expneurol.2019.02.008

Figure 1. Dim light at night (dLAN) impairs recovery from a cardiac arrest and cardiopulmonary resuscitation (CA).

Figure 1.

(a) Experimental outline for figure 1. Groups included n = 8 – 27 starting and n = 8 – 15 surviving; see supplemental Table 1). (b) Kaplan Meier curve illustrates short-term mortality during the first week following cardiac arrest/CPR (CA). (c) dLAN exposure reduced body mass in mice that underwent the CA procedure. (d) dLAN exacerbates CA induced neuronal damage in the hippocampus, as indicated by increased Fluoro-JadeC (FJC) staining relative to LD. Representative FJC stained sections (20X) from the CA1 region of the hippocampus: (e) Sham-dark night (LD-sham) (f) Sham-dim light at night (dLAN-sham) (g) CA-dark night (CA-LD) and (h) CA-dLAN at one week following the CA/sham procedure. Data were analyzed using a two-way ANOVA with Tukey’s post hoc test. The data in panel b represents mean±SEM; the dagger represents a significant main effect (p<0.05) between sham and CA, while the asterick indicates a significant difference (p<0.05) between CA-LD and CA-dLAN.