Table 2.
Comparison of characteristics and symptoms of patients with ESBL-positive Escherichia coli and Klebsiella pneumoniae bacteremia (data shown as number (%) unless indicated)
| Total (n = 72) | ESBL—E. coli (n = 55) | ESBL—K. pneumoniae (n = 17) | P-value | |
|---|---|---|---|---|
| Demographic data | ||||
| Age (years), median (IQR) | 53 (32–65) | 56 (45–65) | 24 (0.41–54) | 0.0097 |
| ≤ 15 year old, n/N (%) | 9/72 (12) | 2/55 (3.6) | 7/17 (41) | < 0.001 |
| Male, n/N (%) | 35/72 (49) | 26/55 (47) | 9/17 (53) | 0.68 |
| Symptoms | ||||
| Days ill, median (IQR) | 3.5 (2–7) | 3 (2–7) | 4 (2–7) | 0.77 |
| Fever, n/N (%) | 68/70 (97) | 55/55 (100) | 13/15 (86) | 0.04 |
| Rigors, n/N (%) | 40/69 (58) | 34/54 (63) | 6/15 (40) | 0.11 |
| Headache, n/N (%) | 36/69 (52) | 31/54 (57) | 5/15 (33) | 0.09 |
| Arthralgia, n/N (%) | 23/69 (33) | 19/54 (35) | 4/15 (27) | 0.75 |
| Back pain, n/N (%) | 24/69 (35) | 18/54 (33) | 6/15 (40) | 0.63 |
| Myalgia, n/N (%) | 35/69 (51) | 30/54 (55) | 5/15 (33) | 0.12 |
| Retro-orbital pain, n/N (%) | 1/65 (2) | 1/50 (2) | 0/15 (0) | 1.00 |
| Jaundice, n/N (%) | 13/67 (19) | 12/52 (23) | 1/15 (7) | 0.26 |
| Nausea, n/N (%) | 20/68 (29) | 17/53 (32) | 3/15 (20) | 0.52 |
| Vomiting, n/N (%) | 17/68 (25) | 14/53 (26) | 3/15 (20) | 0.74 |
| Dysuria, n/N (%) | 13/68 (19) | 11/53 (21) | 2/15 (13) | 0.71 |
| Diarrhea, n/N (%) | 8/68 (12) | 6/53 (11) | 2/15 (13) | 1.00 |
| Constipation, n/N (%) | 4/67 (6) | 4/53 (7) | 0/14 (0) | 0.57 |
| Abdominal pain, n/N (%) | 16/66 (24) | 12/51 (23) | 4/15 (27) | 1.00 |
| Sore throat, n/N (%) | 3/66 (5) | 2/51 (4) | 1/15 (7) | 0.54 |
| Drowsiness, n/N (%) | 13/66 (20) | 10/51 (19) | 3/15 (20) | 1.00 |
| Risk factor | ||||
| Diabetes, n/N (%) | 12/63 (19) | 9/51 (17) | 3/12 (25) | 0.25 |
| Excess alcohol, n/N (%) | 7/60 (12) | 6/48 (12) | 1/12 (8) | 1.00 |
| Smokes, n/N (%) | 9/58 (15) | 8/46 (17) | 1/12 (8) | 0.66 |
| Chronic renal failure, n/N (%) | 7/64 (11) | 6/50 (12) | 1/14 (7) | 0.91 |
| Renal calculi, n/N (%) | 8/61 (13) | 7/47 (15) | 1/14 (7) | 0.63 |
| Steroid use, n/N (%) | 3/52 (6) | 2/41 (5) | 1/11 (9) | 0.75 |
| Reported antibiotic use in the previous week, n/N (%) | 23/44 (52) | 18/35 (51) | 5/9 (56) | 1.00 |
| Outcome | ||||
| Discharged alive, n/N (%) | 22/39 (56) | 16/28 (57) | 6/11 (55) | 0.79 |
| Died in hospital, n/N (%) | 9/39 (23) | 7/28 (25) | 2/11 (18) | |
| Discharged moribund, n/N (%) | 8/39 (20) | 5/28 (18) | 3/11 (27) | |
ESBL = extended-spectrum beta-lactamase.