Table 3.
Antimicrobial susceptibility of extended-spectrum beta-lactamase–producing Escherichia coli and Klebsiella pneumoniae isolated from blood cultures between 2010 and 2014 at Mahosot Hospital, Vientiane, Lao PDR
| Year | 2010 | 2011 | 2012 | 2013 | 2014 | P-value |
|---|---|---|---|---|---|---|
| Antimicrobial | n/N (%) | n/N (%) | n/N (%) | n/N (%) | n/N (%) | |
| Ampicillin | 0/7 (0) | 0/14 (0) | 0/17 (0) | 0/15 (0) | 0/19 (0) | NA |
| Co-amoxiclav | 2/7 (29) | 3/14 (21) | 8/17 (47) | 7/15 (47) | 4/19 (21) | 0.55 |
| Cefalotin | 0/7 (0) | 0/14 (0) | 0/17 (0) | 0/15 (0) | 0/19 (0) | NA |
| Ceftazidime | 1/5 (20) | 3/12 (25) | 4/14 (28) | 2/15 (13) | 4/19 (21) | 0.96 |
| Ceftriaxone | 0/7 (0) | 0/14 (0) | 0/17 (0) | 0/15 (0) | 0/19 (0) | NA |
| Ciprofloxacin | 1/1 (100) | ND | ND | 6/13 (46) | 5/15 (33) | 0.81 |
| Chloramphenicol | 4/7 (57) | 7/14 (50) | 8/17 (47) | 9/15 (60) | 13/19 (68) | 0.51 |
| Doxycycline | ND | ND | ND | 1/4 (25) | 1/3 (33) | 1.00 |
| Gentamicin | 5/7 (71) | 3/14 (21) | 8/17 (47) | 8/15 (53) | 10/19 (52) | 0.15 |
| Meropenem | 6/6 (100) | 12/12 (100) | 15/15 (100) | 15/15 (100) | 17/17 (100) | NA |
| Imipenem | 7/7 (100) | 13/13 (100) | 13/13 (100) | 15/15 (100) | 15/15 (100) | NA |
| Ofloxacin | 4/7 (57) | 5/14 (36) | 9/17 (53) | 8/15 (53) | 6/19 (31) | 0.53 |
| Co-trimoxazole | 0/7 (0) | 3/14 (21) | 4/17 (23) | 4/15 (27) | 3/19 (16) | 0.70 |
| Tetracycline | ND | 1/1 (100) | ND | 3/11 (27) | 2/11 (18) | 0.37 |
| Amikacin | 6/6 (100) | 12/12 (100) | 15/15 (100) | 15/15 (100) | 16/17 (94) | 1.00 |
n = number of isolates susceptible to tested antimicrobial; N = total number of isolates tested; ND = not done; NA = not applicable. Figures in parentheses are percentages. Variations in denominators reflect the fact that not all isolates were tested against each agent.