Table 1.
Variables, sources, and time frames; Zika Outcomes and Development in Infants and Children investigation, Paraíba, Brazil, 2017
| Variable | Source | Child age when assessed |
|---|---|---|
| Demographics | ||
| Child | ZODIAC assessment (medical record abstraction) | 19–26 months |
| Child | Case–control records (medical record and assessment) | Birth and 1–7 months |
| Caregiver | ZODIAC assessment (self-report) | 19–26 months |
| Laboratory evidence of infection | ||
| Child | Case–control (Zika and dengue IgM antibody and neutralization antibody testing of infant specimens) | 1–7 months |
| Medical outcomes | ||
| Dysmorphic features | Case–control (expert clinical evaluation) | 1–7 months |
| Anthropometric parameters | ZODIAC (medical record and assessment) and Case–control records | Birth, 1–7 months, and 19–26 months |
| Neuromotor function | ZODIAC (physician assessment, Hammersmith Infant Neurological Examination25) | 19–26 months |
| Cerebral palsy | ZODIAC (physician assessment) | 19–26 months |
| Hearing impairment | ZODIAC (physician assessment and abstraction of diagnostic evaluation results) | Approximately 19–26 months |
| Vision impairment (abnormalities of retina and fixation/following) | ZODIAC (physician assessment and functional vision and ophthalmologic examination) | 19–26 months |
| Seizures | ZODIAC assessment (parent report and seizure screener) | 19–26 months |
| Other medical conditions and hospitalization | ZODIAC (medical record abstraction) | ≤ 19 months |
| Developmental delay | ||
| Developmental quotient and developmental age equivalent | ZODIAC assessment (parent report and Ages and Stages Questionnaires, third edition27) | 19–26 months |
ZODIAC = Zika Outcomes and Development in Infants and Children.