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. 2020 Apr 30;7:52. doi: 10.3389/fcvm.2020.00052

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Copyright © 2020 Xiang, Grosso, Takeda, Pan, Bekkhus, Brulois, Dermadi, Nordling, Vanlandewijck, Jalkanen, Ulvmar and Butcher.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A continuum of human LEC phenotypes in trajectory space. Principal component projections of trajectory distances reveal complex zonation of LEC subsets and intermediates. (A) 3D projections with LEC subset identities defined by correlation with populations in the index human sample (left) or by unsupervised clustering as described in (27) (right). (B) Expression pattern of indicated genes. Marco-LEC, Ptx3-LEC, and cLEC s1 populations are highlighted. Values are batch-corrected imputed log counts.