Table 2.

Performance of variables in predicting clinical outcomes.

Outcomes	Predictors	AU ROC	95% CI	P	Cut-off	Sensitivity (%)	Specificity (%)	PPV	NPV	LR+	LR-
Need for IRVS	CRB	0.77 ± 0.05	0.69-0.85	<0.001	1	72	79.1	48.6	91.1	3.45	0.35
	CRB				2	28	96.7	70	83	8.49	0.74
	CRB-65	0.81 ± 0.05	0.73-0.88	<0.001	1	88	45.1	30.6	93.2	1.6	0.27
	CRB-65				2	64	93.4	72.7	90.4	9.71	0.39
	CRB-65				3	24	97.8	75	82.4	10.92	0.78
	CURB-65	0.85 ± 0.05	0.77-0.91	<0.001	1	88	42.9	29.7	92.9	1.54	0.28
	CURB-65				2	80	87.9	64.5	94.1	6.62	0.23
	CURB-65				3	52	96.7	81.2	88	15.77	0.5
	CURB-65				4	12	98.9	75	80.4	10.92	0.89
	qSOFA	0.70 ± 0.06	0.60-0.78	<0.001	1	80	47.3	29.4	89.6	1.52	0.42
	qSOFA				2	24	98.9	85.7	82.6	21.84	0.77

Abbreviations: AUROC, area under the receiver operating characteristic curve; CI, confidence interval; LR, likelihood ratio; PPV, positive predictive values; NPV, negative predictive value; CRB, confusion, respiratory rate, and blood pressure; CRB-65, confusion, respiratory rate, blood pressure and age ≥65 years; CURB-65, confusion, urea nitrogen, respiratory rate, blood pressure and age ≥65 years; qSOFA, quick Sepsis-related Organ Failure Assessment; IRVS, intensive respiratory or vasopressor support. Bold: the optimal cut-off values according to Youden index.

AUC comparisons

CRB-65 vs. qSOFA, P=0.02; CRB-65 vs. CRB, P=0.22; CRB-65 vs. CURB-65, P=0.08; CRB vs. qSOFA, P=0.09.