Table 2.
Pharmacokinetic parameters of epiprogoitrin after oral administration (n = 6) at the doses of 20, 25, and 30 mg/kg. Data were expressed as mean ± S.D.
| 20 mg/kg | 25 mg/kg | 30 mg/kg | |
|---|---|---|---|
| Cmax(μg/L) | 700.21 ± 177.50 | 745.42 ± 303.17 | 1001.95 ± 179.38 |
| Tmax(h) | 1.5 ± 0.55 | 1.39 ± 0.56 | 1.42 ± 0.65 |
| AUC0-t(μg/L*h) | 2327.36 ± 477.85 | 2843.43 ± 448.06 | 3299.57 ± 617.90 |
| AUC0-∞(μg/L*h) | 2330.82 ± 478.32 | 2840.92 ± 447.86 | 3301.09 ± 617.47 |
| t1/2(h) | 1.13 ± 0.30 | 1.33 ± 0.33 | 0.97 ± 0.14 |
| MRT0-t(h) | 2.27 ± 0.070 | 2.28 ± 0.25 | 2.52 ± 0.07 |
| MRT0-∞(h) | 2.28 ± 0.067 | 2.30 ± 0.25 | 2.52 ± 0.07 |
| Vd(L/kg) | 15.33 ± 4.64 | 14.57 ± 6.69 | 13.42 ± 4.40 |
| CL(L/kg/h) | 9.55 ± 2.42 | 9.23 ± 2.19 | 9.41 ± 2.07 |
| F(%) | 9.3 | 7.3 | 8.7 |