Table 3.

Pharmacokinetic parameters of progoitrin after oral administration (n = 6) at the doses of 20, 25, and 30 mg/kg. Data were expressed as mean ± S.D.

	20 mg/kg	25 mg/kg	30 mg/kg
Cmax(μg/L)	597.29 ± 161.09	677.98 ± 44.03	740.30 ± 103.27
Tmax(h)	2.10 ± 0.51	1.33 ± 0.52	1.29 ± 0.56
AUC0-t(μg/L*h)	2190.49 ± 399.70	2295.82 ± 364.48	2427.18 ± 331.66
AUC0-∞(μg/L*h)	2191.51 ± 403.48	2297.97 ± 364.54	2430.31 ± 331.97
t1/2(h)	1.17 ± 0.15	0.99 ± 0.1	1.12 ± 0.08
MRT0-t(h)	2.59 ± 0.23	2.61 ± 0.07	2.63 ± 0.08
MRT0-∞(h)	2.60 ± 0.22	2.62 ± 0.07	2.65 ± 0.08
Vd(L/kg)	12.85 ± 1.79	13.89 ± 2.7	21.06 ± 2.97
CL(L/kg/h)	7.69 ± 1.21	8.74 ± 1.35	8.09 ± 1.86
F(%)	34.1	26.9	20.1