Table 4.
Pharmacokinetic parameters of epiprogoitrin and progoitrin after intravenous administration (n = 6) at the dose of 2 mg/kg. Data were expressed as mean ± S.D.
| Components | Cmax(μg/L) | t1/2(h) | AUC0-t(μg/L*h) | AUC0-∞(μg/L*h) | MRT0-t(h) | MRT0-∞(h) | Vd(L/kg) | CLz(L/kg /h) |
|---|---|---|---|---|---|---|---|---|
| progoitrin | 1197.44 ± 284.76 | 1.11 ± 0.154 | 767.903 ± 84.712 | 768.124 ± 84.76 | 0.827 ± 0.036 | 0.831 ± 0.035 | 4.185 ± 0.506 | 2.629 ± 0.279 |
| epiprogoitrin | 3276.483 ± 497.368 | 2.89 ± 0.53 | 2558.845 ± 311.21 | 2563.128 ± 306.943 | 0.851 ± 0.097 | 0.941 ± 0.197 | 7.92 ± 4.56 | 0.79 ± 0.092 |