Table 1.
Demographics, Ventilation parameters, Treatment modalities, Laboratory results, MRI and CSF findings and follow-up data of patients.
| Case 1 | Case 2 | Case 3 | Case 4 | Case 5 | Case 6 | ||
|---|---|---|---|---|---|---|---|
| Demographics | Age (yrs) | 49 | 59 | 59 | 51 | 55 | 22 |
| Gender | M | M | M | F | M | M | |
| Co morbidities | None | HT | HT, DM, Obesity | HT, DM | HT | Autism | |
| Ventilation | mode | PCV | PCV | PCV | PCV | PCV | PCV |
| parameters | PC | 16cmH2O | 20cmH2O | 27cmH2O | 21cmH2O | 28cmH2O | 26cmH2O |
| PEEP | 14cmH2O | 14cmH2O | 16cmH2O | 14cmH2O | 16cmH2O | 14cmH2O | |
| FiO2 | 70% | 50% | 70% | 50% | 60% | 70% | |
| Prone ventilation | 3 times | 2 times | 3 times | No | 3 times | 3 times | |
| Intubation days | 19 | 14 | 14 | 14 | 25 | 15 | |
| Treatment | Antibiotics | LOP/RIT, AZI, CEF, HC, FAV | AZI, HC, FAV | AZI, HC, FAV | AZI, HCFAV | AZI, HCFAV | AZI, HC, FAV |
| WBC 10^3/uL | 26.53 | 20.21 | 17.08 | 11.49 | 42.70 | 17.83 | |
| Platelets 10^3/uL | 202 | 540 | 140 | 660 | 299 | 664 | |
| CRP (<0.5) mg/L | 135 | 82.9 | 32.7 | 142.2 | 732.3 | 431.8 | |
| Serum | D-dimer (0–0.5) mg/L | 6.27 | 6.6 | 0.73 | 0,91 | 6.97 | 7.93 |
| LDH (85–227) IU/L | 560 | 304 | 414 | 271 | 709 | 1110 | |
| IL-6 pg/mL (<7 pg/mL) | 481 | – | – | – | 510 | 9192 | |
| Ferritin (10–291) ng/mL | 1763 | 2918 | 896 | 612 | 5235 | 555 | |
| MRI date (day) | 13 | 15 | 15 | 12 | 15 | 14 | |
| MRI | MRI Result | Encephalitis | Encephalitis | Normal | Normal | Normal | Encephalitis |
| Treatment | Plasmapheresis cycles | 6 | 9 | 1 | 5 | 5 | 3 |
| Outcome | Discharge from ICU | 21 | 19 | Exitus | 21 | Still in ICU | 17 |
| Protein (15–40) mg/dL | 37.6 | 73.2 | 65.7 | 131 | 52.00 | 57.00 | |
| CSF | Glucose (40–70) mg/dL | 130 | 201 | 121 | 120 | 67 | 59 |
| Cell count | 0 | 0 | 0 | 0 | 0 | 0 | |
| CSF IgG mg/L (0 – 3.4 mg/dL | – | 4.27 | 4.68 | 3.23 | 6.66 | 5.71 | |
| IgG Index (<0.60) | – | 0.330 | 0.450 | 0.780 | 0.380 | 0.520 | |
| AlbQ (<9.0) | – | 13.5 | 8.87 | 5.14 | 14.1 | 10.0 | |
| Oligoclonal band | – | None | None | None | None | None | |
HT: Hypertension; DM: Diabetes mellitus; PCV: Pressure controlled ventilation, PC: pressure controlled level. PEEP: positive end-expiratory pressure, FiO2: fraction of inspired oxygen. ICU: Intensive care unit. WBC: White blood cells, CRP: C-reactive protein, LDH: Lactate dehydrogenase, CSF: cerebrospinal fluid, LOP: Lopinavir, RIT. Ritonavir, AZI: Azitromisin, HC: Hydroxychloroquine, CEF: Ceftriaxone, FAV: Faviripavir;. IL-6: interleukin-6. MRI: magnetic resonance imaging, AlbQ: albumin quotient.