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C reactive protein (CRP) inhibits function, costimulatory and checkpoint proteins on dendritic cells (DCs). Frequency of mature (A) and immature (B) DCs treated with CRP at 10 and 40 μg/mL for 48 hours expressed costimulatory markers (CD40, CD80, CD83, CD86, PD-L1, HLA-ABC, HLA-DR and beta-2 microglobulin). Representative data are from one of five patients. Error bars are +SEM for triplicate samples assessed. **P<0.05, **p<0.01, ***p<0.001 relative to cells with no treatment.
