Paper	Bowel Regimen	Patient Instructions
Prospective Trials
Hookey and Vanner, 2009	1-PSLx* 1700 and 2200 evening prior + 10mg Bisacodyl po days 2, 3 pre-colonoscopy 2-PSLx 1700 and 2200 alone evening prior 3-45mL oral NaPhos 1700 and 2200 evening prior	CF only day prior 3-4L of Gatorade or similar evening prior
Fowler et al., 2009	All: PSLx mixed in 150–200 mL H2O + 10mg Bisacodyl po days 2, 3 pre-colonoscopy +Before 11am: (traditional)1 package PSLx 1700 then 2200 After 11am: (split-dose) 1 package PSLX day prior 1900, then 5h prior to procedure	4L CF including Gatorade up to 2h before procedure
Fleming et al., 2012	ALL +10mg Bisacodyl days 2, 3 pre-colonoscopy 1-PSLx at 5pm then 11pm day before 2-PSLx at 7pm evening prior, then 4h prior to colonoscopy	CF only day prior 3–4 L of Gatorade or similar
Melicharkova et al., 2013	1-LRB no later than 10am with CF after 2-CF until 2h prior to colonoscopy 10mg Bisacodyl @1700 day 2, 3 pre-colonoscopy then 2x PSLx Before 11am: 2x at 2200 day prior After 11am: 2x at 0600 day of colonoscopy
Fleming et al., 2015	1-LRB + CF day prior to colonoscopy 2-CF diet alone ALL: 4L PEG-ELS Before 11am: (traditional), 4L over 1-3h starting 1900 After 11am: (split-dose) 2L over 1h at 1900, 2L over 1h 4 hours prior to colonoscopy	LRB – low reside breakfast no later than 10am with CF only after CF up to 2h prior to colonoscopy
Clinical Practice Diary Studies
Vanner and Hookey, 2011	PSLx + 10mg Bisacodyl at 1800 days 2,3 pre-colonoscopy Before 11am: (traditional) 1 package PSLx 1700 then 2200 After 11am: (split-dose) 1 package PSLx evening prior 1900, then 0600 day of	CF day prior, 4L Gatorade or similar day prior until leaving home Diary record average BM x 1wk, times of preparation, times of new BM, amount of sports drink + overall fluids
Arya et al., 2014	Bowel prep chosen by individual gastroenterologists, PEG or PSLx + bisacodyl (10mg days 2, 3 prior to colonoscopy) Before 11am: 1 package PSLx 1700 then 2200, OR 4L PEG over 1-3h starting 1900 After 11am: 1 package PSLx evening prior 1900 and 0600 day of. OR 2L PEG over 1h at 1900 on day prior and 2L L over 1h 4 hours prior to colonoscopy

Abbreviations: PSLx, pico-salax (picosulfate, magnesium oxide, citric acid); LRB, low residue breakfast; CRD, clear residue diet; CF, clear fluids; po, by mouth ⁺As per protocol in the current centre, split-dosing was used for all patients with colonoscopy appointments scheduled after 11:00 am and traditional dosing was used for appointments before 11:00 am. Individuals living far distances could not tolerate split-dose schedule.