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. 2020 Apr 16;8(1):e000323. doi: 10.1136/jitc-2019-000323

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Expression levels of immune checkpoints and corresponding ligands in the brain tumor hemisphere and contralateral hemisphere. (A) Relative expression of immune checkpoints on analyzed T lymphocyte subpopulations in both hemispheres. (B) Relative expression of immune checkpoint ligands on analyzed brain-resident microglia and infiltrating myeloid cells in both hemispheres. MHC-II, class II major histocompatibility complex; PD-1, programmed cell death 1; TIGIT, T cell immunoreceptor with Ig and ITIM domains; HVEM. Herpes virus entry mediator; Tim-3, T-cell immunoglobulin and mucin-domain containing-3; Lag-3, lymphocyte-activation gene 3; PD-L1, programmed death ligand 1; BTLA, B- and T-lymphocyte attenuator.