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Ras, Rho, and Arf subfamilies’ GAP mechanism. A) PDB 1FTN. In RhoA‐GTP, the key catalytic glutamine (Q63, RhoA nomenclature) is oriented away from the nucleotide. B) PDB ITX4. Upon RhoGAP binding, is Q63 oriented towards a water molecule ready to catalyze hydrolysis of GTP. The arginine finger (R85, RhoGAP nomenclature) helps to stabilize the negative charge of the transition state (modelled as GDP and ALF4).
