Table 1.
GEFs, GAPs, and GDIs mentioned in this review. Most research on identifying small molecule therapeutics has been concentrated on the Ras, Rho, and Arf GEF families.
|
GTPase subfamily |
GEF subfamily |
GEFs |
GAPs |
GDIs |
|---|---|---|---|---|
|
Ras |
Cdc25 |
Sos, Epac1/2, RasGRF1 |
NF1‐GAP |
N/A[a] |
|
|
|
|
|
|
|
Rho |
Dbl |
Trio, GEF‐H1, Vav2, ITSN, Tiam1, LARG, Dbs, PDZ‐RhoGEF |
MgcRacGAP |
RhoGDI1 |
|
|
DOCK |
DOCK1, DOCK2, DOCK5 |
|
|
|
|
|
|
|
|
|
Rab |
|
NI[b] |
NI[b] |
NI[b] |
|
|
|
|
|
|
|
Ran |
|
NI[b] |
NI[b] |
N/A[a] |
|
|
|
|
|
|
|
Arf |
Sec7 |
CYTH1, ARNO, BIG1, GBF1 |
ArfGAP1 |
N/A[a] |
|
|
Sec12 |
NI[b] |
[a] This subfamily does not have GDIs. [b] No inhibitors in this review