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. 2020 Apr 22;10(4):e034351. doi: 10.1136/bmjopen-2019-034351

Table 3.

Relative risk of death in patients for different treatment intervals

Variables Unadjusted Adjusted
HR P value HR 95% CI P value*
Interval from cancer diagnosis to treatment
 ≤7 days (ref.)
 8~14 days 1.26 <0.001 1.04 1.01 to 1.07 0.004
 15~60 days 1.30 <0.001 1.06 1.04 to 1.09 <0.001
 ≥61 days 1.66 <0.001 1.08 1.04 to 1.11 <0.001
Gender
 Female (ref.)
 Male 1.54 <0.001 1.50 1.47 to 1.53 <0.001
Age (years)
 ≤44 (ref.)
 45~54 0.97 0.357 0.97 0.92 to 1.03 0.351
 55~64 1.02 0.478 1.03 0.97 to 1.09 0.331
 65~74 1.63 <0.001 1.27 1.21 to 1.34 <0.001
 ≥75 1.93 <0.001 1.79 1.69 to 1.88 <0.001
Monthly salary
 Low income (ref.)
 ≤17 280 0.72 <0.001 0.89 0.80 to 1.00 0.049
 17 281~22 800 0.81 <0.001 0.86 0.78 to 0.95 0.002
 22 801~28 800 0.74 <0.001 0.83 0.75 to 0.91 <0.001
 28 801~36 300 0.60 <0.001 0.79 0.71 to 0.87 <0.001
 36 301~45 800 0.59 <0.001 0.78 0.70 to 0.87 <0.001
 ≥45 801 0.56 <0.001 0.73 0.66 to 0.81 <0.001
Urbanisation level
 Level 1 (ref.)
 Level 2 1.07 <0.001 0.99 0.96 to 1.02 0.523
 Level 3 1.20 <0.001 1.04 1.00 to 1.07 0.036
 Level 4 1.21 <0.001 1.01 0.98 to 1.05 0.596
 Level 5 1.33 <0.001 1.01 0.95 to 1.08 0.671
 Level 6 1.39 <0.001 1.09 1.04 to 1.15 0.001
 Level 7 1.25 <0.001 1.02 0.96 to 1.07 0.570
CCI score
 ≤3 (ref.)
 4~6 1.35 <0.001 1.18 1.14 to 1.21 <0.001
 ≥7 1.80 <0.001 1.28 1.25 to 1.31 <0.001
Other catastrophic illness
 No (ref.)
 Yes 1.25 <0.001 1.26 1.19 to 1.33 <0.001
Cancer stage
 Stage I (ref.)
 Stage II 2.29 <0.001 2.06 1.91 to 2.23 <0.001
 Stage III 4.48 <0.001 3.94 3.75 to 4.13 <0.001
 Stage IV 6.51 <0.001 5.89 5.62 to 6.17 <0.001
MDT care
 No (ref.)
 Yes 0.95 0.001 0.91 0.88 to 0.94 <0.001
Hospital level
 Medical centres (ref.)
 Regional hospitals 1.28 <0.001 0.99 0.96 to 1.02 0.347
 District hospitals 2.06 <0.001 1.25 1.17 to 1.34 <0.001
 Others 1.17 0.137 0.90 0.73 to 1.10 0.286
Hospital ownership
 Public (ref.)
 Private 1.27 <0.001 1.13 1.10 to 1.16 <0.001
Hospital services volume
 Low (ref.)
 Middle 0.72 <0.001 0.83 0.81 to 0.85 <0.001
 High 0.59 <0.001 0.71 0.68 to 0.74 <0.001

*Cox proportional hazards regression.

CCI, Charlson Comorbidity Index; MDT, multidisciplinary team.