FIGURE 3.

Post-translational modification crosstalks in sirtuin interactor proteins. (A) The frequency of proteins with number of PTM types at each site. Apart from the first bar (with single PTM type), the rest have in situ crosstalks. (B) cis and in situ crosstalks for sirtuin interactors reveal that most crosstalks occur in CVDs and other diseases, whereas very few (only 6% sites) were not involved with any disease. The in situ crosstalk seems to play an important role in CVDs in sirtuin interactors. (C) The frequency of proteins in each bin of in situ crosstalk sites reveals that most proteins have 1–10 crosstalk sites. Few proteins have more than 50 such sites.