Table 3.
List of prioritized protein targets with their drug target information and “druggability” features.
| Gene | RNs | Drug targets* | Drug(s)# | Disease(s)# | PDB | DS |
|---|---|---|---|---|---|---|
| ADAM10 | 5.34 | Yes | XL784 | Solid tumor/cancer, Breast cancer | 6BE6 | 0.694 |
| TIMP1 | 4.79 | No | NA | NA | 1LQN | 0.839 |
| EGF | 4.77 | Yes | Sucralfate, Tesevatinib, Alpha-Aminobutyric Acid, Cholecystokinin | Oral mucositis, Vulnerary | template: 5GJE | 0.968 |
| MATN3 | 3.31 | No | NA | NA | template: 6BXJ | 0.545 |
| CALU | 3.17 | No | NA | NA | template: 2Q4U | 0.677 |
| APLP2 | 3.12 | Yes | Zinc, Zinc acetate, Zinc chloride | NA | 5TPT | 0.912 |
| ITGAV | 3.08 | Yes | Abituzumab, Levothyroxine |
Colorectal cancer, Solid tumour/cancer | 3IJE | 0.663 |
| VCAN | 3.05 | Yes | Hyaluronic acid | NA | template: 4CSY | NA |
| LGALS1 | 3.03 | Yes | Thiodigalactoside, 1,4-Dithiothreitol, Mercaptoethanol, Artenimol | NA | 3W59 | NA |
| ITGA2 | 3.027 | No | NA | NA | Templates: 3K71, 4NEH, 3K6S | 0.672 |
| ALB | 2.85 | Yes | Gadobenate Dimeglumine, Glycyrrhizic acid, Patent Blue, (365 drugs) | Hemophilia, Schizophrenia | 4BKE | 1.000 |
| PKM | 2.82 | Yes | Pyruvic acid, L-Phospholactate, 2-Phosphoglycolic Acid, et al. |
Pain, Renal cell carcinoma; | 6GG5 | 0.996 |
| MFGE8 | 2.54815 | No | NA | NA | template: 4DEQ | NA |
| APOL1 | 2.52 | Yes | Zinc, Zinc acetate, Zinc chloride | NA | template: 5J2L | 0.503 |
| ACTN1 | 2.45 | Yes | Copper, Human calcitonin | NA | template: 4D1E | 0.673 |
| BST2 | 2.31 | No | NA | NA | 3MQB | 0.821 |
| MSLN | 2.0 | Yes | Amatuximab | Ovarian/Pancreatic cancer | 4F3F | 0.727 |
*”YES” means drug target, and “NO” means non-drug target; #”NA” means no drug and disease information, or no druggable pockets.