Table 4.
Top 10 enriched KEGG pathways (integrins and collagens are marked in bold).
| KEGG term | Gene(s) | Count | Adjust p-value |
|---|---|---|---|
| ECM-receptor interaction | COL1A1, COL1A2, COL6A3, COMP, FN1, ITGA2, ITGA3, ITGA5, ITGAV, ITGB4, ITGB5, LAMB3, LAMC2, SDC1, SDC4 | 15 | 2.62E-11 |
| Focal adhesion | ACTB, ACTN4, ACTN1, BIRC3, COL1A1, COL1A2, COL6A3, COMP, EGF, FLNA, FN1, ITGA2, ITGA3, ITGA5, ITGAV, ITGB4, ITGB5, LAMB3, LAMC2, PDGFRB | 20 | 2.67E-11 |
| Proteoglycans in cancer | ACTB, COL1A1, COL1A2, FLNA, FN1, ITGA2, ITGA5, ITGAV, ITGB5, LUM, MMP9, MSN, PLAU, PLAUR, SDC1, SDC4, EZR, WNT2, WNT5A | 19 | 2.97E-10 |
| Human papillomavirus infection | CCNA2, COL1A1, COL1A2, COL6A3, COMP, EGF, FN1, HLA-F, ITGA2, ITGA3, ITGA5, ITGAV, ITGB4, ITGB5, LAMB3, LAMC2, MX1, PDGFRB, PKM, PRKCI, STAT1, WNT2, WNT5A | 23 | 4.12E-10 |
| Regulation of actin cytoskeleton | ACTB, ACTN4, ACTN1, CFL1, CHRM3, EGF, FN1, ITGA2, ITGA3, ITGA5, ITGAV, ITGB4, ITGB5, MSN, PDGFRB, EZR, ARPC1B | 17 | 8.45E-10 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ACTB, CTNNA1, ITGA2, ITGA3, ITGA5, ITGAV, ITGB4, ITGB5, JUP | 9 | 1.25E-05 |
| PI3K-Akt signaling pathway | COL1A1, COL1A2, COL6A3, COMP, EGF, EPHA2, FN1, IL2RG, ITGA2, ITGA3, ITGA5, ITGAV, ITGB4, ITGB5, LAMB3, LAMC2, PDGFRB | 17 | 3.87E-05 |
| Amoebiasis | ACTN4, ACTN4, ACTN1, COL1A1, COL1A2, COL3A1, FN1, CXCL8, LAMB3, LAMC2 | 9 | 1.03E-04 |
| Hypertrophic cardiomyopathy (HCM) | ACTB, ITGA2, ITGA3, ITGA5, ITGAV, ITGB4, ITGB5, TPM4 | 8 | 3.01E-04 |
| Small cell lung cancer | BIRC3, CKS2, FN1, ITGA2, ITGA3, ITGAV, LAMB3, LAMC2 | 8 | 3.01E-04 |