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. 2020 Mar 30;33(108):85–88.

Table 3.

Antiviral prophylaxis for the prevention of re-activation of HSV ocular infections

Drug Dose / regimen Comment
Systemic aciclovir Aciclovir 400 mg orally twice a day There is strong evidence12 that the use of prophylactic systemic aciclovir reduces the recurrence of:
Any form of ocular HSV infection (19% aciclovir vs. 32% control; p < 0.001)
Herpes simplex keratitis specifically (14% aciclovir vs. 28% control; p < 0.005)