Skip to main content
. Author manuscript; available in PMC: 2020 May 7.
Published in final edited form as: Commun Chem. 2019 Jul 3;2:77. doi: 10.1038/s42004-019-0172-x

Fig. 4.

Fig. 4

X-ray crystal of mitoNEET with furosemide used to develop novel derivatives. a Docked poses of compounds, 2f, 2l, and 2n to illustrate the ability to design compound to interact with HIS87, LYS55, and LYS68; b, c Pharmacophore query for the binding pocket from docking studies. The furosemide bound mitoNEET structure was used for the docking study. d Binding curves of compounds in the presence of [3H]rosiglitazone