Table 4. Comparison of different screening strategies.
| Screening Algorithms | Colposcopy referral rate % | Cytology testing rate % | CIN2+ | CIN3+ | ||
|---|---|---|---|---|---|---|
| Sen% | Spe% | Sen% | Spe% | |||
| 1.CobasHPV+ | 10.78* | NA | 95.1* (135/142) | 90.4* (9271/10257) | 100 (54/54) | 89.7* (9278/10345) |
| 2.HPV16/18+ | 2.61* | NA | 49.3* (70/142) | 98.0* (10056/1025) | 68.5* (37/54) | 97.7* (10111/10345) |
| 3.HPV+ then Cyto≥ASCUS | 3.39* | 10.8* | 73.2* (104/142) | 97.6%* (10008/10257) | 100 (54/54) | 97.1* (10046/10345) |
| 4.HPV16/18+ then Cyto≥ASCUS of 12 other subtypes | 4.90 | 8.2 | 83.1 (118/142) | 96.2 (9865/10257) | 100 (54/54) | 95.6 (9889/10345) |
| 5.HPV16/18+ then HPV-Ct≤27 of 12 Other subtypes | 4.40*# | NA | 66.9*# (95/142) | 96.5*# (9894/10257) | 81.5*# (44/54) | 96.0*# (9931/10345) |
| 6.HPV16/18+ then HPV-Ct≤31 of 12 Other subtypes | 6.59* | NA | 80.3 (114/142) | 94.4* (9686/10257) | 92.6 (50/54) | 93.9* (9710/10345) |
| 7.HPV16/18+ then HPV-Ct≤35 of 12 Other subtypes | 8.57*# | NA | 86.6# (123/142) | 92.5*# (9489/10257) | 96.3 (52/54) | 91.9*# (9506/10345) |
Abbreviations: algorithm#1: if CobasHPV positive, refer to colposcopy;
algorithm #2: if HPV16/18 positive, refer to colposcopy
algorithm #3: if HPV positive, underwent cytology, cytology≥ASCUS, refer to colposcopy
algorithm#4: if HPV16/18 positive, refer to colposcopy;12 other HPV subtype positive, underwent cytology, cytology≥ASCUS, refer to colposcopy
algorithm #5: if HPV16/18 positive, refer to colposcopy;12 other HPV subtype positive, HPV-Ct ≤27 of 12 other subtypes refer to colposcopy
algorithm #6: if HPV16/18 positive, refer to colposcopy;12 other HPV subtype positive, HPV-Ct ≤31 of 12 other subtypes refer to colposcopy
algorithm #7: if HPV16/18 positive, refer to colposcopy;12 other HPV subtype positive, HPV-Ct ≤35 of 12 other subtypes refer to colposcopy
*: Compared with algorithm#4, P < 0.05;
#: When algorithm#5 and #7 were compared with algorithm#6, P < 0.05.