Table 1. Biacore binding analysis of top viscosity reducing clones.
Ligand | ka (1/Ms) | kd(1/s) | KD (pM) |
---|---|---|---|
AB-001 | 5.05E+06±7.82E+05 | 4.57E-04±6.26E-05 | 94.83±29.21 |
R1-016 | 4.88E+06±4.97E+05 | 3.57E-04±3.81E-05 | 74.35±13.74 |
R2-001 | 3.09E+06±7.74E+05 | 2.92E-04±2.79E-05 | 102.49±32.34 |
R2-006 | 3.97E+06±6.25E+05 | 3.36E-04±6.01E-05 | 88.80±29.47 |
R2-020 | 2.04E+06±1.04E+05 | 6.10E-04±1.70E-05 | 298.69±6.83 |
This table shows the Biacore binding kinetics of AB-001 and the top viscosity reducing clones including the binding on-rate (ka), the binding off-rate kd and the equilibrium dissociation constant (KD).