Table 2. Downregulated KEGG pathways in renal cancer cells transfected with si-RAB27B.
| KEGG ID | Annotations | Number of genes | Corrected P-value | Genes |
|---|---|---|---|---|
| 5016 | Huntington's disease | 18 | 0.001028 |
NDUFA2,NDUFS8,POLR2G,ATP5D,AP2S1, POLR2L,PPID,NDUFB10,COX5B,DCTN4, NDUFB3,SOD2,NDUFA1,POLR2J3, NDUFA11,POLR2I,NDUFS7,COX7A2L |
| 5012 | Parkinson's disease | 15 | 0.001299 |
NDUFA2,NDUFS8,ATP5D,PPID,UBE2L6, NDUFB10,COX5B,UBE2J2,NDUFB3, NDUFA1,UCHL1,NDUFA11,NDUFS7, COX7A2L,UBB |
| 280 | Valine, leucine and isoleucine degradation | 9 | 0.001448 |
ACAT2,ALDH1B1,ACADM,MCCC1, ALDH6A1,ABAT,HMGCL,ACADSB,AOX1 |
| 4120 | Ubiquitin mediated proteolysis | 14 | 0.004448 |
UBE2C,DDB2,UBE2L6,ANAPC13,UBE2J2, BIRC3,SYVN1,ERCC8,ANAPC11,RBX1, UBE2S,TCEB2,RNF7,STUB1 |
| 240 | Pyrimidine metabolism | 11 | 0.006179 |
NT5C,POLR2G,POLR3K,POLR2L,ITPA, DTYMK,POLD4,POLR2J3,TK1,POLR3E, POLR2I |
| 3020 | RNA polymerase | 6 | 0.006328 |
POLR2G,POLR3K,POLR2L,POLR2J3, POLR3E,POLR2I |
| 3008 | Ribosome biogenesis in eukaryotes | 9 | 0.012605 |
FCF1,SBDS,UTP18,NOP58,NXT2,GTPBP4, POP5,GNL3,RPP25 |
| 4114 | Oocyte meiosis | 11 | 0.014851 |
ESPL1,CCNB2,PTTG1,ANAPC13,RPS6KA2, MAPK12,PLK1,ANAPC11,PPP3CA,RBX1, PPP1CB |
| 5010 | Alzheimer's disease | 14 | 0.015760 |
BAD,CASP7,NDUFA2,NDUFS8,ATP5D, NDUFB10,COX5B,CAPN2,NDUFB3,PPP3CA, NDUFA1,NDUFA11,NDUFS7,COX7A2L |
| 190 | Oxidative phosphorylation | 12 | 0.015966 |
NDUFA2,NDUFS8,ATP5D,NDUFB10, COX5B,NDUFB3,ATP6V0C,NDUFA1, ATP6V1E2,NDUFA11,NDUFS7,COX7A2L |
| 900 | Terpenoid backbone biosynthesis | 4 | 0.017628 | ACAT2,MVD,IDI1,IDI2 |
| 4510 | Focal adhesion | 15 | 0.023570 |
BAD,RELN,PGF,PDGFC,RAC2,BIRC3, CAPN2,CAV1,RAC3,VASP,ITGAV,FYN, CTNNB1,MYL5,PPP1CB |
| 4110 | Cell cycle | 11 | 0.023941 |
ESPL1,CCNB2,PTTG1,ANAPC13,SFN, STAG2,PLK1,ANAPC11,CCNA1,RBX1, CDKN1C |
| 380 | Tryptophan metabolism | 6 | 0.024668 | ACAT2,CAT,ALDH1B1,KMO,CYP1B1,AOX1 |
| 4370 | VEGF signaling pathway | 8 | 0.031072 |
BAD,RAC2,PLA2G6,MAPK12,RAC3, PPP3CA,KRAS,HSPB1 |
| 5210 | Colorectal cancer | 7 | 0.032788 |
BAD,TGFBR1,RAC2,RAC3,KRAS,APPL1, CTNNB1 |
| 4122 | Sulfur relay system | 3 | 0.033906 | MPST,TST,CTU1 |
| 640 | Propanoate metabolism | 5 | 0.034257 | ACAT2,ALDH1B1,ACADM,ALDH6A1,ABAT |
| 4670 | Leukocyte transendothelial migration | 10 | 0.036059 |
CLDN2,CTNNA1,RAC2,CYBA,MAPK12, VASP,NCF2,CTNNB1,MYL5,CLDN14 |
| 4010 | MAPK signaling pathway | 17 | 0.038571 |
CACNA2D1,RPS6KA5,NGF,IKBKG, MAP3K13,TGFBR1,RAC2,PLA2G6, RPS6KA2,GNG12,MAPK12,RAC3,RRAS2, PPP3CA,KRAS,HSPB1,DUSP14 |
| 4520 | Adherens junction | 7 | 0.049024 |
CTNNA1,TGFBR1,PTPRM,RAC2,RAC3, FYN,CTNNB1 |
| 5200 | Pathways in cancer | 19 | 0.049311 |
BAD,CTNNA1,PGF,IKBKG,TGFBR1,RAC2, TPM3,BIRC3,WNT5B,RAC3,ITGAV,KRAS, APPL1,CEBPA,CCNA1,CTNNB1,RBX1, FLT3LG,TCEB2 |
| 3010 | Ribosome | 8 | 0.049395 |
RPL13,RPS19,RPL5,RPL18,RPS13, RPL36AL,RPS29,RPS20 |
| 4914 | Progesterone-mediated oocyte maturation | 8 | 0.049395 |
CCNB2,ANAPC13,RPS6KA2,MAPK12, PLK1,ANAPC11,KRAS,CCNA1 |
KEGG, Kyoto Encyclopedia of Genes and Genomes.