Figure 5. The pancreas supports engraftment and growth of ccRCC with PBRM1 loss.

(A and H) Images of tumors growing in the pancreas of 7 NOD/SCID host mice from 2 different patients with PBRM1 mutations. Dotted black circles demarcate the tumor areas. (B and I) Ultrasound images of tumor growth. (C and J) Images of harvested tumors from indicated mice. (D and K) Tumor volumes at implantation and harvest. (E and L) H&E staining of the tumors showing pancreatic interface in red; P-pancreas; T-tumor. (F and M) PBRM1 and (G and N) CD31 IHC studies. **P < 0.01.