Figure 7. Synergy effect of Erb-IL21 with checkpoint blockade in advanced tumors.
C57BL/6 mice (n = 7–9) were inoculated with 2.5 × 105 MC38-cEGFR cells and were i.p. treated with 75 μg hIgG, 200 μg anti–CTLA-4, 200 μg anti-PD-L1, 75 μg Erb-IL21, or combinations as indicated on days 14, 16, and 20. (A) Tumor growth was measured twice weekly. (B) Survival curve. The mean ± SEM values are shown. Two-way ANOVA tests were used to analyze the tumor growth data. *P < 0.05, **P < 0.01. One of two representative experiments is shown.