Figure 7. The role of S1P-derived sPRR on glucose metabolism in DIO mice.

Male C57/BL6 mice were fed a HFD for 9 months and were treated with vehicle, PF alone, or PF in combination with sPRR-His for the last 2 weeks. (A) Plasma glucose. (B) Plasma insulin. (C) GTT. (D) ITT. n = 9 per group. *P < 0.05 vs. DIO group, ^#P < 0.05 vs. DIO + PF group. For C and D, xy analyses with area under curve and unpaired Student’s t test were performed. For A and B, statistical significance was determined by using ANOVA with the Bonferroni test for multiple comparisons. Data are shown as mean ± SEM.