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. 2020 May 7;15(5):e0232777. doi: 10.1371/journal.pone.0232777

Table 3. emm type distribution of the macrolide-susceptible and macrolide-resistant group A streptococcal isolates.

emm Type n Macrolide-susceptiblea Macrolide-resistanta Residualb P value Adjusted P valuec
emm1 92 91 (21.1) 1 (1.2) -4.4 <0.001 <0.001
emm89 71 66 (15.3) 5 (5.9) -2.3 0.021 0.300
emm4 65 60 (13.9) 5 (5.9) -2.0 0.049 0.586
emm12 60 51 (11.8) 9 (10.6) -0.3 0.749 1.000
emm28 58 21 (4.9) 37 (43.5) 10.3 <0.001 <0.001
emm3 56 56 (13.0) 0 (0) -3.5 <0.001 0.006
emm75 30 29 (6.7) 1 (1.2) -2.0 0.046 0.644
emm6 24 24 (5.5) 0 (0) -2.2 0.026 0.365
emm77 23 0 (0) 23 (27) 11.1 <0.001 <0.001
emm2 14 14 (3.2) 0 (0) -1.7 0.092 1.000
emm11 11 8 (1.8) 3 (3.5) 1.0 0.327 1.000
emm87 4 4 (0.9) 0 (0) -0.9 0.373 1.000
emm48 2 2 (0.5) 0 (0) -0.6 0.530 1.000
Other 7 6 (1.4)d 1 (1.2)e -0.2 0.877 1.000
Total 517 432 (100.0) 85 (100.0)

a Number, percent in parentheses

b Standardized residuals method [36] for the significance of difference between macrolide-susceptible and macrolide-resistant rates

c Bonferroni correction for multiple comparisons

d emm Type (number of isolates): emm8 (n = 1); emm44 (n = 1); emm65 (n = 1); emm76 (n = 1); emm118 (n = 1); emm192 (n = 1)

e emm Type (number of isolates): emm58 (n = 1)