Fig 1. Cdc13 suppresses unstable chromosomes through its activity with CST/t-RPA.

(A) Chr VII disome system. The two homologues of Chr VII are in black or grey. Position of CAN1 and 6 heterozygous markers are shown. (B) i: Schematic of the different rearrangements recovered in the Chr VII assay. ii: Model of the unstable chromosome’s fate on a cellular level. (C) Frequency of unstable chromosomes in cdc13 mutants from cells grown at 25°C (blue) or 30°C (red). The median frequency, IQR, and statistically significant fold changes relative to the permissive temperature are noted (* < 0.01; Mann-Whitney U).