Table 1. Median frequencies of chromosome instability in cdc13F684S at 25 and 30°C.
| Temp | Strain | Sectored (×10−5) |
Round (×10−5) |
Chromosome Loss (×10−5) |
|---|---|---|---|---|
| 25° | Wild Type (CDC13+) | 3.6 [5.6] (1.0) | 6.3 [15] (1.0) | 15 [320] (1.0) |
| cdc13F684S | 3.3 [4.6] (0.92) | 5.7 [7.5] (0.90) | 130 [2000] (8.7) | |
| cdc13Y556A,Y558A | 20 [18] (5.6) | 25 [11] (4.0) | 81 [137] (5.4) | |
| stn1T223A,S250A | 9.5 [5.5] (2.6) | 11 [6.7] (1.7) | 87 [130] (5.8) | |
| cdc13F684S stn1T223A,S250A | 7.7 [2.9] (2.1) | 12 [7.1] (1.9) | 110 [360] (7.3) | |
| 30° | Wild Type (CDC13+) | 2.9 [3.4] (1.0) | 7.1 [4.5] (1.0) | 12 [38] (1.0) |
| cdc13F684S | 88 [120] (30) | 20 [20] (2.8) | 73 [93] (6.1) | |
| cdc13Y556A,Y558A | 150 [170] (52) | 51 [92] (7.2) | 210 [260] (18) | |
| stn1T223A,S250A | 3.0 [2.0] (1.0) | 6.0 [7.0] (0.85) | 20 [27] (1.7) | |
| cdc13F684S stn1T223A,S250A | 280 [420] (97) | 20 [25] (2.8) | 140 [70] (12) |
Median values and IQR, in []s, are reported.
In bold, statistically significant (P < 0.01, Mann-Whitney U) fold change between single mutants and Wild Type (CDC13+) or between cdc13F684S mutX and cdc13F684S from the corresponding temperature.
Normalized median frequencies are reported in ()s (normalized to CDC13+ from the corresponding temperature).