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. 2020 Apr 27;16(4):e1008458. doi: 10.1371/journal.ppat.1008458

Fig 5. Schematic model of Hyd involvement in the IMD signaling pathway in Drosophila.

Fig 5

Model showing the role of Hyd in the expression of the Akirin-dependent genes in the IMD pathway. After activation of the pathway, allowed by the K63-polyUb chains deposition on the complexes IMD and DREDD by the E3-ubiquitin ligase Diap2, Relish is translocated. Hyd is necessary for the K63-polyUb of the NF-κB co-factor Akirin and its interaction with the NF-κB factor Relish. This interaction is crucial for the expression of Akirin-dependent genes (like Attacin-A and Attacin-C), necessary for an adequate innate immune response. DAP-PGN: meso-diaminopimelic acid-type peptidoglycan of Gram-negative bacteria, P-tag: phosphorylation marks.