Table 2.

Association of a mitochondrial PRS and mitochondrial haplogroups (model 1) and their interactions (model 2) with baseline risk of Alzheimer’s disease

Variable	Model 1			Model 2
	βa	SE	p	β	SE	p
Age	0.02	0.02	0.213	0.03	0.02	0.122
Male	−0.01	0.22	0.975	−0.09	0.23	0.682
APOE status
ε4+	1.2	0.24	6.47E-07	1.25	0.25	5.08E-07
ε2+	−0.7	0.58	0.227	−0.88	0.6	0.142
PC1	−0.14	0.13	0.274	−0.1	0.13	0.423
PC2	0.53	0.55	0.332	0.42	0.55	0.442
nMT-PRS	0.79	0.14	5.58E-09	1.09	0.2	5.68E-08
Haplogroup
I	0.27	0.62	0.661	0.33	0.63	0.6
J	0.09	0.4	0.827	0.06	0.44	0.886
K	0.694	0.35	0.049	0.71	0.34	0.038
T	−0.23	0.4	0.564	0.04	0.38	0.909
U	0.687	0.35	0.052	0.81	0.38	0.033
V	0.01	0.63	0.988	0.07	0.76	0.926
W	0.66	0.9	0.464	0.74	0.86	0.391
X	−1.23	1.13	0.278	−2.04	1.77	0.247
Haplogroup × nMT-PRS
I	-	-	-	−0.38	0.84	0.647
J	-	-	-	0.28	0.68	0.685
K	-	-	-	−0.8	0.36	0.026
T	-	-	-	−1.51	0.41	2.18E-04
U	-	-	-	0.07	0.52	0.886
V	-	-	-	1.01	1.44	0.482
W	-	-	-	−0.68	0.85	0.425
X	-	-	-	−2.31	1.97	0.24

Key: APOE, apolipoprotein E; nMT-PRS, nuclear-encoded mitochondrial polygenic risk score; PC1, principal component 1; PC2, principal component 2.

^aResults in the main text are presented as the exponentiation of the beta. p-values are unadjusted.