Table 3.

Association of a mitochondrial PRS and mitochondrial haplogroups (model 1) and their interactions (model 2) with Alzheimer’s disease age of onset

Variable	Model 1			Model 2
	βa	SE	p	βa	SE	p
Male	−0.21	0.1	0.0034	−0.22	0.1	0.028
APOE status
ε4+	0.8	0.12	6.50E-12	0.78	0.12	2.70E-11
ε2+	−0.85	0.39	0.029	−0.86	0.39	0.027
PC1	−0.11	0.06	0.073	−0.1	0.06	0.104
PC2	0.03	0.04	0.525	0.03	0.04	0.509
nMT-PRS	0.36	0.06	3.54E-10	0.37	0.08	2.55E-06
Haplogroup
I	−0.01	0.26	0.958	0.04	0.28	0.879
J	−0.06	0.17	0.707	−0.09	0.19	0.635
K	−0.06	0.18	0.742	−0.05	0.18	0.78
T	−0.31	0.17	0.073	−0.14	0.18	0.422
U	−0.1	0.15	0.528	−0.16	0.17	0.35
V	0.17	0.28	0.549	−0.26	0.38	0.496
W	0.38	0.33	0.247	0.38	0.33	0.241
X	0.08	0.32	0.794	0.16	0.36	0.664
Haplogroup × nMT-PRS
I	-	-	-	−0.14	0.29	0.617
J	-	-	-	0.08	0.22	0.72
K	-	-	-	−0.06	0.17	0.74
T	-	-	-	−0.48	0.2	0.015
U	-	-	-	0.14	0.15	0.371
V	-	-	-	0.82	0.33	0.013
W	-	-	-	0.13	0.34	0.697
X	-	-	-	−0.13	0.32	0.68

Key: APOE, apolipoprotein E; nMT-PRS, nuclear-encoded mitochondrial polygenic risk score; PC1, principal component 1; PC2, principal component 2.

^aResults in the main text are presented as the exponentiation of the beta.