Table 5.

Association of a mitochondrial PRS and mitochondrial haplogroups (model 1) and their interactions (model 2) with Alzheimer’s disease age of onset adjusting for PRS excluding nMT genes and APOE

Variable	Model 1			Model 2
	βa	SE	p	βa	SE	p
Male	−0.34	0.1	8.06E-04	−0.35	0.1	6.78E-04
APOE status
ε4+	0.78	0.11	6.42E-12	0.77	0.12	3.32E-11
ε2+	−0.71	0.39	0.069	−0.73	0.39	0.064
PC1	−0.3	0.07	7.63E-06	−0.28	0.07	3.26E-05
PC2	0.05	0.04	0.207	0.05	0.04	0.194
PRS w/o nMT & APOE	1.03	0.09	3.56E-29	1.03	0.09	2.63E-28
nMT-PRS	0.15	0.06	0.018	0.17	0.08	0.041
Haplogroup
I	−0.26	0.26	0.302	−0.15	0.28	0.597
J	0.08	0.18	0.632	0.06	0.19	0.748
K	−0.11	0.18	0.521	−0.09	0.19	0.623
T	−0.14	0.17	0.417	−0.08	0.18	0.631
U	−0.13	0.16	0.396	−0.14	0.17	0.413
V	0.22	0.28	0.426	−0.29	0.41	0.489
W	0.47	0.33	0.149	0.5	0.33	0.124
X	−0.02	0.33	0.949	0.21	0.37	0.57
Haplogroup × nMT-PRS
I	-	-	-	−0.26	0.28	0.366
J	-	-	-	0.09	0.22	0.668
K	-	-	-	−0.11	0.17	0.505
T	-	-	-	−0.22	0.21	0.282
U	-	-	-	0.01	0.16	0.927
V	-	-	-	0.88	0.39	0.025
W	-	-	-	0.26	0.35	0.455
X	-	-	-	−0.37	0.34	0.278

Key: APOE, apolipoprotein E; nMT-PRS, nuclear-encoded mitochondrial polygenic risk score; PC1, principal component 1; PC2, principal component 2.

^aResults in the main text are presented as the exponentiation of the beta.