Table 5.
Multivariable models used to adjust associations of cognitive decline measures with inter-arm difference
| Variablea | Decline in MMSE score ≥5 | Composite outcome | ||
|---|---|---|---|---|
| OR | P-value | OR | P-value | |
| Age | 1.09 | <0.001 | 1.07 | <0.001 |
| Sex | 1.20 | 0.267 | 1.35 | 0.037 |
| Baseline MMSE | 1.02 | 0.617 | 0.94 | 0.050 |
| Years in education | 0.91 | 0.003 | 0.90 | <0.001 |
| Systolic blood pressure | 1.01 | 0.235 | 1.00 | 0.980 |
| Ankle–brachial index | 1.58 | 0.397 | 0.52 | 0.184 |
| Diabetes | 1.49 | 0.068 | 1.96 | 0.002 |
| Previous cerebrovascular event | 2.22 | 0.020 | 1.53 | 0.231 |
| Duration of follow-up | 1.02 | <0.001 | 1.02 | <0.001 |
a
Variables dropped from models on backward stepwise regression: baseline cardiovascular disease; baseline diastolic blood pressure; hypercholesterolaemia; smoking status; body mass index; and carotid stenosis ≥40%. MMSE = mini mental state examination. OR = odds ratio.