How this fits in

Systolic inter-arm difference in blood pressure (IAD) is associated with increased cardiovascular and all-cause mortality. Cognitive decline is associated with hypertension and cerebrovascular disease, and may be mitigated by aggressive blood pressure lowering in those most at risk. Detection of an IAD may identify individuals at excess risk of cognitive decline. This study found initial evidence that systolic inter-arm differences ≥5 mmHg or ≥10 mmHg are associated with markers of cognitive decline over a median 9-year follow-up period. Recognition of IAD as a risk marker for cognitive decline may help to inform personalised discussion of blood pressure lowering and other preventive strategies in reducing the risk of cognitive decline.