Table 3.

Mean Cognitive Function Scores With Adjustment for (a) Age, Education, Race/Ethnicity, Clinic, and Intervention Assignment and (b) With Additional Adjustment for Summed Brain Volumes, Summed WMH Volumes, and Average CBF

Cognitive Test†	Z-score Mean (SE)		Mean Difference: Women Minus Men
	Women	Men	Mean (SE)	95% CI
Adjustment for age, education, race/ethnicity, clinic, and intervention assignment
3MSE	0.196 (0.062)	0.000 (0.097)	0.195 (0.118)	[−0.037, 0.427]
AVLT
Immediate	0.145 (0.067)	−0.399 (0.104)	0.544 (0.127)	[0.295, 0.793]*
Delayed	0.290 (0.068)	−0.412 (0.107)	0.702 (0.129)	[0.447, 0.956]*
Stroop	0.098 (0.058)	0.233 (0.091)	−0.135 (0.111)	[−0.353, 0.083]
DSC	0.190 (0.058)	−0.018 (0.091)	0.208 (0.111)	[−0.009, 0.426]
Trail Making
A	0.139 (0.053)	0.160 (0.083)	−0.021 (0.101)	[−0.220, 0.178]
B	0.090 (0.060)	0.081 (0.088)	0.010 (0.107)	[−0.200, 0.220]
Composite	0.170 (0.041)	−0.024 (0.064)	0.193 (0.077)	[0.042, 0.346]*
Additional adjustment for intracranial volume, summed brain volumes, summed WMH volumes, and mean CBF
3MSE	0.227 (0.070)	−0.105 (0.119)	0.332 (0.153)	[0.030, 0.634]*
AVLT
Immediate	0.105 (0.073)	−0.316 (0.125)	0.422 (0.162)	[0.103, 0.740]*
Delayed‡	0.244 (0.075)	−0.324 (0.127)	0.570 (0.165)	[0.244, 0.892]*
Stroop‡	0.148 (0.065)	0.135 (0.111)	0.013 (0.143)	[−0.268, 0.295]
DSC‡,§	0.245 (0.065)	−0.122 (0.111)	0.367 (0.143)	[0.086, 0.648]*
Trail Making
A‡,||	0.203 (0.058)	0.032 (0.100)	0.171 (0.129)	[−0.083, 0.425]
B‡	0.121 (0.062)	−0.021 (0.106)	0.142 (0.136)	[−0.126, 0.410]
Composite‡,§	0.195 (0.045)	−0.090 (0.077)	0.285 (0.100)	[0.089, 0.481]*

*Confidence interval excludes 0.

^†3MSE: Modified Mini-Mental State Exam; AVLT: Rey Auditory Verbal Learning Test; Stroop: Modified Stroop Color and Word Test; DSC: Digit Symbol Coding test.

^‡Significant relationship with summed brain volumes (p ≤ .05).

^§Significant inverse relationship with summed WMH volumes (p ≤ .05).

^||Significant inverse relationship with average CBF (p ≤ .05).