Figure 5. Chronic administration of AM-8123 induces known APJ signaling pathways.

Western blots reveal an increase in (A) ERK and a trend toward increased (B) AKT phosphorylation in LV cardiac tissue collected from a subset of animals as part of the study presented within Figure 4. Individual data points (circles, n = 5–6) and group mean (bars) ± SEM are shown. Significance measured by a 2-tailed unpaired t test. See full blots in Supplemental Figures 19 and 20.