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. 2020 Apr 23;5(8):e136907. doi: 10.1172/jci.insight.136907

Figure 2. GLP-2 treatment in HFHC diet–fed mice does not effect hepatic inflammation.

Figure 2

Experimental endpoints in mice fed a HFHC or CD for 17 weeks and treated with GLP-2 for 11 days, as illustrated in Figure 1A (n = 9–10 per group for all panels). (A) Transaminase plasma levels in cardiac blood at termination. § significant diet effect on ALT variance, P < 0.01. (B) Protein concentrations of inflammatory markers in liver normalized to hepatic protein levels. (C) Hepatic mRNA abundance, relative to Ppia, of genes relevant to inflammatory pathways. Data are presented as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001, §P < 0.05, significant effect of diet on gene expression variance, using 2-way ANOVA with Tukey correction for multiple comparisons.