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. 2020 Apr 23;5(8):e136907. doi: 10.1172/jci.insight.136907

Figure 6. Hepatic stellate cell activation markers are elevated in Glp2r–/– mice on HFHC diet and in aged mice.

Figure 6

(A) mRNA abundance, relative to Ppia, of hepatic stellate cell activation markers in hepatic RNA from Glp2r+/+ and Glp2r–/– mice on HFHC or CD as outlined in Figure 3A (n = 9–10 per group). (B) Representative Sirius red staining of liver sections with quantification of Sirius red–positive staining (left) and liver mRNA abundance, relative to Ppia, of fibrosis markers Col1a1and Acta2 (right) (n = 9–10 per group). Scale bar: 100 μm. (C) mRNA levels, relative to Ppia, of stellate cell activation markers in livers from Glp2r+/+ and Glp2r–/– male mice age 50 ± 3.5 weeks old (n = 4 each). Data are presented as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, using 2-way ANOVA with Tukey correction for multiple comparisons or Student’s t test where appropriate.