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. 2020 Apr 23;5(8):e132446. doi: 10.1172/jci.insight.132446

Figure 5. SNPs regulate IL1RL1 mRNA and protein expression levels in response to asthma-relevant microenvironments.

Figure 5

(A–C) Increased release of IL1RL1 protein in response to HDM was present in 3 of our 4 selected signals: Signal A (rs995514; proxy for rs12474258) for the protective allele for asthma and elevated blood eosinophils (C) (P < 0.05), Signal C (rs17027258; proxy for rs72825929) risk allele for severe asthma (A) (P < 0.01), and Signal D (rs10192157) for the protective allele for asthma (T) (P < 0.05) (A [CC, n = 8; TC/TT, n = 8], B [AA, n = 11; AG/GG, n = 5], and C [CC, n = 8; TC/TT, n = 10], respectively). (D) Decreased levels of total IL1RL1 mRNA in response to HDM is present only in Signal B (rs4142132) for carriers of the allele protective for reductions in lung function (FEV1) (G) (AA, n = 4; AG, n = 5; GG, n = 4; P < 0.05). Statistics were run using a Kruskal-Wallis test. Data are represented by Tukey box and whisker plots, where the box covers data from the 25th to the 75th percentiles, with the center line denoting the median of the data. Whisker plots identify the interquartile range as determined by the Tukey method, with resulting outlier data displayed as distinct points outside the whiskers.