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. Author manuscript; available in PMC: 2020 May 7.
Published in final edited form as: Transl Res. 2016 Dec 9;183:71–86.e1. doi: 10.1016/j.trsl.2016.12.002

Figure 2. Reduced Nrf2-regulated gene signature in SSc skin biopsies.

Figure 2

The 30 genes most up- and down-regulated in lung fibroblasts with siNrf2 and siKeap1 knockdown were designated as the “Nrf2 signature” [22]. Expression of these genes was interrogated in SSc transcriptomes (NCBI GEO GSE9285 and GSE32413) [2]. A. Supervised hierarchical clustering of skin biopsy transcriptomes [2] without application of filtering criteria. 26 genes up-regulated (upper panel) and 19 genes down-regulated (lower panel) by Nrf2 present in this dataset. Biopsies from patients in the normal-like subset show gene expression most similar to healthy control skin biopsies. B. The Nrf2 signature score shows inverse correlation with the LPS signature score. P<0.001.