Table 2.

Cortical surface maturation metrics at term-equivalent age from structural MRI with and without adjustment for known clinical predictors and prediction of Bayley-III cognitive and language scores at 2 years corrected age in very preterm infants

Predictors	Cortical metrics only		Final models with covariates
	Coefficients (95% CI)	P value	Coefficients (95% CI)	P value
Cognitive scores	Adjusted R2 0.34		Adjusted R2 0.39
Surface area of the parietal lobe (R) (cm2)	0.58 (0.32 to 0.83)	<0.001	0.55 (0.27 to 0.83)	<0.001
Curvature of the posterior part of the cingulate gyrus (L)*	−5.75 (−9.78 to −1.72)	0.006	−4.68 (−8.64 to 0.71)	0.021
Curvature of the temporal lobe (L)	−10.32 (−19.63 to −1.01)	0.030	−10.21 (−19.33 to −1.09)	0.029
Socioeconomic status			7.37 (1.63 to 13.11)	0.013
Gestational age			−0.43 (−1.86 to 1.00)	0.548
Male sex			−1.11 (−6.92 to 4.69)	0.703
Global injury score on structural MRI			−1.00 (−2.43 to 0.43)	0.168
Language scores	Adjusted R2 0.35		Adjusted R2 0.40
Curvature of the superior temporal gyrus (L)	−10.17 (−15.17 to 5.17)	<0.001	−8.59 (−13.64 to −3.54)	0.001
Curvature of the insula (L)	−17.46 (−25.65 to −9.26)	<0.001	−15.02 (−23.08 to −6.96)	<0.001
Surface area of the parietal lobe (L) (cm2)	0.50 (0.20 to 0.79)	0.001	0.38 (0.06 to 0.70)	0.021
Socioeconomic status			7.06 (0.57 to 13.56)	0.034
Gestational age			0.93 (−0.69 to 2.56)	0.255
Male sex			−3.22 (−9.89 to 3.45)	0.338
Global injury score on structural MRI			−0.33 (−1.95 to 1.29)	0.685

^*Curvature is a unitless metric that ranges from +1 to −1.