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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Glia. 2020 Jan 16;68(7):1347–1360. doi: 10.1002/glia.23779

FIGURE 1.

FIGURE 1

RvE1-mediated effects on memory. (a) Two-way ANOVA results by karyotype and RvE1 treatment on behavior in the WRAM and NORT tests. (b) Over 3 days, Ts65Dn mice displayed significantly more errors than the NS mice throughout the WRAM task, and RvE1 treatment significantly enhanced Ts65Dn performance to that observed in all NS mice. (c) In a cognitive flexibility task, RvE1 treatment significantly enhanced Ts65Dn performance to that observed in all NS mice. (d) In the locomotion test, Veh-treated Ts65Dn mice were hyperactive (distance in meters traveled over 60 min) relative to Veh-treated NS mice and RvE1 treatment normalized this behavioral phenotype with no effect on NS mice. (e,f) In the NORT task, Veh-treated Ts65Dn mice displayed severe deficits that were normalized by RvE1 treatment at 90 min (e) and 24 hr (f). The RvE1 treatment had no effects on NS mice at any interval. Tukey’s post hoc p values are shown for group comparisons and error bars represent mean ± SEM. NS, normosomic; NORT, novel object recognition task; RvE1, resolvin E1; TS, Ts65Dn; Veh, vehicle; WRAM, water radial maze task