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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Glia. 2020 Jan 16;68(7):1347–1360. doi: 10.1002/glia.23779

FIGURE 2.

FIGURE 2

Effects of RvE1 on levels of RvE1-binding receptors. Immunoblot signals in the frontal cortex (a) and hippocampus (b) revealed that RvE1 treatment significantly reduced ChemR23, BLT1, and PPAR-γ. (c) Two-way ANOVA effects by karyotype and resolvin (Rv) E1 treatment on levels of ChemR23 and BLT1 were attributed mainly to RvE1 treatment. (d,e) Densitometric analysis showed significant compensatory responses to RvE1-treatment in both NS and Ts65Dn mice for ChemR23 (d) and BLT1 (e) in the frontal cortex and hippocampus. The results of immunoblot signals were normalized to levels in Veh-treated NS mice. Tukey’s post hoc p values are shown for group comparisons and error bars represent the average ± SEM. BLT1, leukotriene B4 receptor 1; ChemR23, chemokine-like receptor 1; NS, normosomic; RvE1, resolvin E1; TS, Ts65Dn; Veh, vehicle