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. Author manuscript; available in PMC: 2020 Oct 6.
Published in final edited form as: Nat Methods. 2020 Apr 6;17(5):515–523. doi: 10.1038/s41592-020-0797-9

Extended Data Fig. 9. Transcription factors that preferentially bind at ssDNA-containing enhancers in HEK293T cells.

Extended Data Fig. 9

a, Metagene profiles of CTCF, YY1, SP1, SP2, MAZ, NCAPH2, KLF8, KLF9, ZNF335, ZNF341, ZBTB20, and ZBTB26 ChIP-seq reads densities at denoted enhancers in HEK293T cells. Regions within 10 kb around the enhancer centers are shown. b, Transcription factor binding motifs enriched at ssDNA-containing enhancers (n = 1,969 enhancers) in HEK293T cells with corresponding p values by using the genome as background. Only TFs with motif information in the TRANSFAC vertebrates library were analyzed. P values were calculated by two-sided binomial test. c, GREAT analysis of genes regulated by ssDNA-containing enhancers (n = 1,969 enhancers) in HEK293T cells. P values were calculated by two-sided binomial test. SSE: ssDNA-containing enhancers; DSAE: double-stranded active enhancers; PE: poised enhancers.